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a beta 2 microglobulin

a beta 2 microglobulin

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a beta 2 microglobulin
Beta-2 microglobulin - Wikipedia, beta 2 microglobulin - General Practice Notebook, Beta-2 Microglobulin Tumor Marker - Lab Tests Online, Beta-2 Microglobulin Tumour Marker - Lab Tests Online UK, Beta-2 Microglobulin - an overview | ScienceDirect Topics, Beta 2 -microglobulin test | definition of beta 2 , , , .
B2MAvailable structuresOrtholog search: PDBe RCSB List of PDB id codes1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1AKJ, 1AO7, 1B0G, 1B0R, 1BD2, 1C16, 1CE6, 1DE4, 1DUY, 1DUZ, 1E27, 1E28, 1EEY, 1EEZ, 1EFX, 1EXU, 1GZP, 1GZQ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1IM9, 1JF1, 1JGD, 1JGE, 1JHT, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1LP9, 1M05, 1M6O, 1MHE, 1MI5, 1OF2, 1OGA, 1OGT, 1ONQ, 1PY4, 1Q94, 1QEW, 1QLF, 1QQD, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1R3H, 1S9W, 1S9X, 1S9Y, 1SYS, 1SYV, 1TMC, 1TVB, 1TVH, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZHK, 1ZHL, 1ZS8, 1ZSD, 1ZT4, 1ZVS, 2A83, 2AK4, 2AV7, 2AXF, 2AXG, 2BCK, 2BNQ, 2BNR, 2BSR, 2BSS, 2BST, 2BVO, 2BVP, 2BVQ, 2C7U, 2CII, 2CIK, 2CLR, 2D31, 2D4D, 2D4F, 2DYP, 2E8D, 2ESV, 2F53, 2F54, 2F74, 2F8O, 2GIT, 2GJ6, 2GT9, 2GTW, 2GTZ, 2GUO, 2H26, 2H6P, 2HJL, 2HLA, 2HN7, 2J8U, 2JCC, 2NW3, 2NX5, 2P5E, 2P5W, 2PO6, 2PYE, 2RFX, 2UWE, 2V2W, 2V2X, 2VB5, 2VLJ, 2VLK, 2VLL, 2VLR, 2X4N, 2X4O, 2X4P, 2X4Q, 2X4R, 2X4S, 2X4T, 2X4U, 2X70, 2X89, 2XKS, 2XKU, 2XPG, 2YPK, 2YPL, 2YXF, 2Z9T, 3AM8, 3B3I, 3B6S, 3BGM, 3BH8, 3BH9, 3BHB, 3BO8, 3BP4, 3BP7, 3BVN, 3BW9, 3BWA, 3BXN, 3BZE, 3BZF, 3C9N, 3CDG, 3CII, 3CIQ, 3CZF, 3D18, 3D25, 3D2U, 3D39, 3D3V, 3DBX, 3DHJ, 3DHM, 3DTX, 3DXA, 3EKC, 3FFC, 3FQN, 3FQR, 3FQT, 3FQU, 3FQW, 3FQX, 3FT2, 3FT3, 3FT4, 3GIV, 3GJF, 3GSN, 3GSO, 3GSQ, 3GSR, 3GSU, 3GSV, 3GSW, 3GSX, 3H7B, 3H9H, 3H9S, 3HAE, 3HCV, 3HG1, 3HLA, 3HPJ, 3HUJ, 3I6G, 3I6K, 3I6L, 3IB4, 3IXA, 3JTS, 3KLA, 3KPO, 3KPR, 3KPS, 3KWW, 3KXF, 3KYN, 3KYO, 3L3D, 3L3G, 3L3I, 3L3J, 3L3K, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3LN4, 3LN5, 3LOW, 3LV3, 3M17, 3M1B, 3MGO, 3MGT, 3MR9, 3MRB, 3MRC, 3MRD, 3MRE, 3MRF, 3MRG, 3MRH, 3MRI, 3MRJ, 3MRK, 3MRL, 3MRM, 3MRN, 3MRO, 3MRP, 3MRQ, 3MRR, 3MV7, 3MV8, 3MV9, 3MYJ, 3MYZ, 3MZT, 3NA4, 3NFN, 3O3A, 3O3B, 3O3D, 3O3E, 3O4L, 3OX8, 3OXR, 3OXS, 3PWJ, 3PWL, 3PWN, 3PWP, 3QDA, 3QDG, 3QDJ, 3QDM, 3QEQ, 3QFD, 3QFJ, 3QZW, 3RL1, 3RWJ, 3S6C, 3SDX, 3SJV, 3SKM, 3SKO, 3SPV, 3T8X, 3TID, 3TIE, 3TLR, 3TM6, 3TO2, 3TZV, 3U0P, 3UPR, 3UTQ, 3UTS, 3UTT, 3V5D, 3V5H, 3V5K, 3VCL, 3VFR, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 3VH8, 3VRI, 3VRJ, 3VWJ, 3VWK, 3W39, 4E0K, 4E0L, 4E5X, 4EN3, 4EUP, 4F7M, 4F7P, 4F7T, 4FTV, 4FXL, 4G8G, 4G8I, 4G9D, 4G9F, 4GKS, 4GUP, 4HKJ, 4I4W, 4JFD, 4JFE, 4JFF, 4JFO, 4JFP, 4JFQ, 4JQX, 4JRX, 4JRY, 4K7F, 4KDT, 4L4T, 4L4V, 1CG9, 1N2R, 1P7Q, 1S8D, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 2AV1, 2FYY, 2FZ3, 2HJK, 3DX6, 3DX7, 3DX8, 3KPL, 3KPM, 3KPN, 3KPP, 3KPQ, 3LOZ, 3OV6, 3REW, 3RL2, 3VXM, 3VXN, 3VXO, 3VXP, 3VXR, 3VXS, 3VXU, 3W0W, 3WL9, 3WLB, 3WUW, 3X11, 3X12, 3X13, 3X14, 4GKN, 4HWZ, 4HX1, 4I48, 4K71, 4L29, 4L3C, 4L3E, 4LCW, 4LCY, 4LHU, 4LNR, 4M8V, 4MJ5, 4MJ6, 4MJI, 4MNQ, 4N0F, 4N0U, 4N8V, 4NNX, 4NNY, 4NO0, 4NO2, 4NO3, 4NO5, 4NQC, 4NQD, 4NQE, 4NQV, 4NQX, 4NT6, 4O2C, 4O2E, 4O2F, 4ONO, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 4PR5, 4PRA, 4PRB, 4PRD, 4PRE, 4PRH, 4PRI, 4PRN, 4PRP, 4QOK, 4QRP, 4QRQ, 4QRR, 4QRS, 4QRT, 4QRU, 4U1H, 4U1I, 4U1J, 4U1K, 4U1L, 4U1M, 4U1N, 4U1S, 4U6X, 4U6Y, 4UQ2, 4UQ3, 4WJ5, 4WO4, 4WU5, 4WU7, 4X6C, 4X6D, 4X6E, 4X6F, 4XXC, 4WDI, 4Z76, 4Z77, 4Z78, 4R9H, 4RA3, 4RAH, 5D2L, 5D2N, 4WW2, 5DEG, 4RMT, 5DEF, 4RMW, 4RMV, 4RMR, 5D7J, 4RMQ, 4RMS, 4WWK, 5BXF, 5D5M, 5D7L, 4RMU, 4WUU, 5D7I, 5EU5, 5EO0, 5EO1, 5EU4, 5BRZ, 5EU6, 5BS0, 5EU3, 5C9J, 5D9S, 5HGA, 5C0D, 5C0B, 5C0I, 5C0A, 5B38, 5E9D, 5B39, 5C0H, 5HHN, 5HGD, 5C08, 5CFH, 5CKG, 4ZEZ, 5C0C, 5HGH, 5C0J, 5HHQ, 5DDH, 5HHM, 5HGB, 5C09, 5HYJ, 5CKA, 5C07, 5HHP, 5C0G, 5C0F, 5HHO, 5C0EIdentifiersB2M, entrez:567, IMD43, beta-2-microglobulin, Β2 microglobulinExternal IDs 109700 88127 2987 B2M Gene location (Human)15q21.1Start44,711,487 End44,718,877 Gene location (Mouse)Chromosome 2 (mouse)2 E5|2 60.55 cMStart122,147,686 End122,153,083 patternMore reference expression dataMolecular function• protein binding• identical protein bindingCellular component• HFE-transferrin receptor complex• Golgi apparatus• phagocytic vesicle membrane• early endosome membrane• endoplasmic reticulum lumen• membrane• focal adhesion• Golgi membrane• plasma membrane• extracellular region• MHC class I protein complex• ER to Golgi transport vesicle membrane• early endosome lumen• extracellular exosome• external side of plasma membrane• extracellular space• cytosol• cell surface• specific granule lumen• recycling endosome membrane• tertiary granule lumen• MHC class I peptide loading complexBiological process• cellular protein metabolic process• positive regulation of receptor-mediated endocytosis• cellular response to iron ion• response to cadmium ion• negative regulation of receptor binding• negative regulation of neuron projection development• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent• T cell differentiation in thymus• immune system process• interferon-gamma-mediated signaling pathway• antigen processing and presentation of peptide antigen via MHC class I• iron ion homeostasis• positive regulation of T cell mediated cytotoxicity• regulation of defense response to virus by virus• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent• regulation of membrane depolarization• antigen processing and presentation of endogenous peptide antigen via MHC class I• positive regulation of ferrous iron binding• positive regulation of transferrin receptor binding• retina homeostasis• positive regulation of T cell cytokine production• protein refolding• immune response• regulation of immune response• positive regulation of receptor binding• positive regulation of protein binding• innate immune response• cellular response to lipopolysaccharide• response to molecule of bacterial origin• response to drug• antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent• iron ion transport• ferric iron import• neutrophil degranulation• regulation of erythrocyte differentiation• cellular response to iron(III) ion• antimicrobial humoral immune response mediated by antimicrobial peptide• positive regulation of ferrous iron import across plasma membrane• regulation of iron ion transportSources:Amigo / QuickGOSpeciesHumanMouse56712010ENSG00000166710ENSG00000273686ENSMUSG00000060802P61769P01887RefSeq (mRNA)NM_004048NM_009735RefSeq (protein)NP_004039NP_033865Location (UCSC)Chr 15: 44.71 – 44.72 MbChr 2: 122.15 – 122.15 Mb search. β 2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells).. Beta-2 microglobulin (B2m) is the 11.8 kDa light-chain moiety of major histocompatibility complex class I (MHC I) present on the surface of nearly all nucleated cells.
Beta-2 microglobulin (B2M) is a protein shed by cells into the blood, including tumor cells. The B2M test can be used as a tumor marker for some people with blood cell cancers (multiple myeloma, lymphoma) to give information about their likely prognosis.. Beta-2 microglobulin (B2M) is a protein that is found on the surface (part of MHC class I) of almost all cells in the body and is shed by cells into the blood, particularly by B lymphocytes and tumour cells.. β-2 microglobulin is a light chain of the major histocompatibility complex; it contains 99 amino acids and has a β-sandwich fold with seven antiparallel β-strands.. Beta 2-microglobulin is a protein found on the surface of many cells. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease.. . .
 
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