ADRB1Available structuresOrtholog search: PDBe RCSB List of PDB id codes2LSQIdentifiersADRB1, ADRB1R, B1AR, BETA1AR, RHR, adrenoceptor beta 1External IDs 109630 87937 20171 ADRB1 Gene location (Human)10q25.3Start114,044,056 End114,046,908 Gene location (Mouse)Chromosome 19 (mouse)19 D2|19 51.96 cMStart56,722,199 End56,733,113 patternMore reference expression dataMolecular function• beta-adrenergic receptor activity• PDZ domain binding• G-protein coupled receptor activity• epinephrine binding• norepinephrine binding• signal transducer activity• adrenergic receptor activity• protein binding• alpha-2A adrenergic receptor binding• protein heterodimerization activity• Ras guanyl-nucleotide exchange factor activity• beta1-adrenergic receptor activity• G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potentialCellular component• integral component of membrane• endosome• membrane• plasma membrane• integral component of plasma membrane• early endosome• Schaffer collateral - CA1 synapse• integral component of postsynaptic density membraneBiological process• positive regulation of cAMP biosynthetic process• fear response• adenylate cyclase-activating G-protein coupled receptor signaling pathway• negative regulation of multicellular organism growth• cell-cell signaling• positive regulation of cAMP-mediated signaling• positive regulation of heart rate by epinephrine-norepinephrine• activation of adenylate cyclase activity• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure• diet induced thermogenesis• adenylate cyclase-activating adrenergic receptor signaling pathway• positive regulation of heart contraction• positive regulation of GTPase activity• positive regulation of the force of heart contraction by epinephrine-norepinephrine• heat generation• brown fat cell differentiation• response to cold• temperature homeostasis• signal transduction• G-protein coupled receptor signaling pathway• adenylate cyclase-modulating G-protein coupled receptor signaling pathway• postsynaptic potential• positive regulation of cold-induced thermogenesisSources:Amigo / QuickGOSpeciesHumanMouse15311554ENSG00000043591ENSMUSG00000035283P08588P34971RefSeq (mRNA)NM_000684NM_007419RefSeq (protein)NP_000675NP_031445Location (UCSC)Chr 10: 114.04 – 114.05 MbChr 19: 56.72 – 56.73 Mb search. Beta is a measure of the volatility, or systematic risk, of a security or a portfolio in comparison to the market as a whole. Beta is used in the capital asset pricing model (CAPM).. The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue..