ADRB2Available structuresOrtholog search: PDBe RCSB List of PDB id codes4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQHIdentifiersADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2External IDs 109690 87938 30948 ADRB2 Gene location (Human)5q32, 5q32Start148,825,245 End148,828,687 Gene location (Mouse)Chromosome 18 (mouse)18 E1|18 35.1 cMStart62,177,816 End62,179,959 patternMore reference expression dataMolecular function• adenylate cyclase binding• adrenergic receptor activity• beta2-adrenergic receptor activity• enzyme binding• protein homodimerization activity• potassium channel regulator activity• protein binding• G-protein coupled receptor activity• signal transducer activity• norepinephrine binding• epinephrine binding• amyloid-beta binding• macromolecular complex bindingCellular component• endosome• membrane• cell nucleus• apical plasma membrane• lysosome• integral component of membrane• receptor complex• plasma membrane• early endosome• integral component of plasma membrane• endosome membrane• clathrin-coated vesicle membraneBiological process• positive regulation of autophagosome maturation• adenylate cyclase-activating G-protein coupled receptor signaling pathway• regulation of sodium ion transport• endosome to lysosome transport• receptor-mediated endocytosis• cell surface receptor signaling pathway• regulation of systemic arterial blood pressure by norepinephrine-epinephrine• negative regulation of smooth muscle contraction• regulation of smooth muscle contraction• adenylate cyclase-modulating G-protein coupled receptor signaling pathway• bone resorption• adenylate cyclase-activating adrenergic receptor signaling pathway• heat generation• desensitization of G-protein coupled receptor protein signaling pathway by arrestin• positive regulation of MAPK cascade• G-protein coupled receptor signaling pathway• positive regulation of bone mineralization• activation of adenylate cyclase activity• brown fat cell differentiation• activation of transmembrane receptor protein tyrosine kinase activity• positive regulation of protein ubiquitination• negative regulation of multicellular organism growth• cell-cell signaling• diet induced thermogenesis• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure• positive regulation of lipophagy• response to cold• positive regulation of transcription from RNA polymerase II promoter• signal transduction• protein deubiquitination• membrane organization• adrenergic receptor signaling pathway• regulation of blood vessel diameter• positive regulation of protein kinase A signaling• positive regulation of mini excitatory postsynaptic potential• positive regulation of protein serine/threonine kinase activity• positive regulation of cold-induced thermogenesis• cellular response to amyloid-beta• response to psychosocial stress• positive regulation of cAMP-dependent protein kinase activity• positive regulation of AMPA receptor activitySources:Amigo / QuickGOSpeciesHumanMouse15411555ENSG00000169252ENSMUSG00000045730P07550P18762RefSeq (mRNA)NM_000024NM_007420RefSeq (protein)NP_000015NP_031446Location (UCSC)Chr 5: 148.83 – 148.83 MbChr 18: 62.18 – 62.18 Mb search. In contrast, Beta-1 adrenergic receptors are coupled only to G s, and stimulation of these results in a more diffuse cellular response. This appears to be mediated by cAMP induced PKA phosphorylation of the receptor. Function. Actions of the β 2 receptor include: Muscular system. This test detects and measures one or more classes (IgG, IgM, or very rarely IgA) of beta-2 glycoprotein 1 antibodies. Beta-2 glycoprotein 1 antibody is a protein c-factro that binds to phospholipids..