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beta 2 rezeptor g protein

beta 2 rezeptor g protein

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beta 2 rezeptor g protein
Beta-2 adrenergic receptor - Wikipedia, Beta-2 adrenergic receptor | Revolvy, Beta 2 adrenergic receptor: A Nobel protein helping you , G protein-coupled receptor - Wikipedia, Beta-2 Adrenergic Receptor-Gs Protein Complex, Beta-2 Adrenergic Receptor - an overview | ScienceDirect , Beta-2 Receptor - G Protein Coupled Receptors , ADRB2 - Beta-2 adrenergic receptor - Homo sapiens (Human , beta 2 receptor Flashcards | Quizlet.
ADRB2Available structuresOrtholog search: PDBe RCSB List of PDB id codes4QKX, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 5D5A, 5D5B, 5JQHIdentifiersADRB2, ADRB2R, ADRBR, B2AR, BAR, BETA2AR, adrenoceptor beta 2External IDs 109690 87938 30948 ADRB2 Gene location (Human)5q32, 5q32Start148,825,245 End148,828,687 Gene location (Mouse)Chromosome 18 (mouse)18 E1|18 35.1 cMStart62,177,816 End62,179,959 patternMore reference expression dataMolecular function• adenylate cyclase binding• adrenergic receptor activity• beta2-adrenergic receptor activity• enzyme binding• protein homodimerization activity• potassium channel regulator activity• protein binding• G-protein coupled receptor activity• signal transducer activity• norepinephrine binding• epinephrine binding• amyloid-beta binding• macromolecular complex bindingCellular component• endosome• membrane• cell nucleus• apical plasma membrane• lysosome• integral component of membrane• receptor complex• plasma membrane• early endosome• integral component of plasma membrane• endosome membrane• clathrin-coated vesicle membraneBiological process• positive regulation of autophagosome maturation• adenylate cyclase-activating G-protein coupled receptor signaling pathway• regulation of sodium ion transport• endosome to lysosome transport• receptor-mediated endocytosis• cell surface receptor signaling pathway• regulation of systemic arterial blood pressure by norepinephrine-epinephrine• negative regulation of smooth muscle contraction• regulation of smooth muscle contraction• adenylate cyclase-modulating G-protein coupled receptor signaling pathway• bone resorption• adenylate cyclase-activating adrenergic receptor signaling pathway• heat generation• desensitization of G-protein coupled receptor protein signaling pathway by arrestin• positive regulation of MAPK cascade• G-protein coupled receptor signaling pathway• positive regulation of bone mineralization• activation of adenylate cyclase activity• brown fat cell differentiation• activation of transmembrane receptor protein tyrosine kinase activity• positive regulation of protein ubiquitination• negative regulation of multicellular organism growth• cell-cell signaling• diet induced thermogenesis• norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure• positive regulation of lipophagy• response to cold• positive regulation of transcription from RNA polymerase II promoter• signal transduction• protein deubiquitination• membrane organization• adrenergic receptor signaling pathway• regulation of blood vessel diameter• positive regulation of protein kinase A signaling• positive regulation of mini excitatory postsynaptic potential• positive regulation of protein serine/threonine kinase activity• positive regulation of cold-induced thermogenesis• cellular response to amyloid-beta• response to psychosocial stress• positive regulation of cAMP-dependent protein kinase activity• positive regulation of AMPA receptor activitySources:Amigo / QuickGOSpeciesHumanMouse15411555ENSG00000169252ENSMUSG00000045730P07550P18762RefSeq (mRNA)NM_000024NM_007420RefSeq (protein)NP_000015NP_031446Location (UCSC)Chr 5: 148.83 – 148.83 MbChr 18: 62.18 – 62.18 Mb search. The beta-2 adrenergic receptor, also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with epinephrine, a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increased cAMP, and downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. The official symbol for the human gene encoding the β2 adrenoreceptor is ADRB2.. Fan G, Shumay E, Wang H, Malbon CC (Jun 2001). "The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization". The Journal of Biological Chemistry. 276 (26): 24005–14..
Every time you smell a flower, taste an apple, get an adrenaline rush from bungee jumping, or even read the words here, you are using G-protein-coupled receptors (GPCRs).. G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.. The Beta-2 Adrenergic Receptor(B2AR) is a single poly-peptide chain which weaves inside and outside of the cellular membrane. Its secondary structure is constituted by 8 α helices, 7 of which are trans-membrane and one which runs parallel to the intracellular face of the cell membrane.. Initial uncoupling of the beta-2 receptor from the G-protein after agonist binding is mediated by phosphorylation of specific residues in the carboxyl tail of the receptor. The phosphorylated beta-2 receptor serves as a substrate for the binding of . The beta 2 adrenergic receptor is a G protein coupled receptor that is coupled to the Gs protein, which activates adenylate cyclase, which catalyzes the formation of cAMP which activates protein kinase A. Actions of this receptor include increased heart rate and contractility as well as increased lipolysis and insulin release.. Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine..
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