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alpha l beta 2

alpha l beta 2

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alpha l beta 2
Integrin alpha L - Wikipedia, Recombinant Human Integrin alpha L beta 2 Protein, CF 3868 , Integrin alpha L beta 2 Products: R&D Systems, alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranose (CHEBI , Alpha-L beta-2 integrin activation on MonoMac6 cells, Cell Motility in Chronic Lymphocytic Leukemia: Defective , alpha-L-Fucp-(1->2)-beta-D-Galp-(1->3)-beta-D-GlcpNAc , alpha-L-Fucosyl-(1->2)-beta-D-galactosyl-(1->4)-[alpha-L , .
ITGALAvailable structuresOrtholog search: PDBe RCSB List of PDB id codes4IXD, 1CQP, 1DGQ, 1LFA, 1MJN, 1MQ8, 1MQ9, 1MQA, 1RD4, 1T0P, 1XDD, 1XDG, 1XUO, 1ZON, 1ZOO, 1ZOP, 2ICA, 2K8O, 2M3E, 2O7N, 3BN3, 3BQM, 3BQN, 3E2M, 3EOA, 3EOB, 3F74, 3F78, 3HI6, 3M6F, 3TCX, 5E6S, 5E6R, 5E6UIdentifiersITGAL, CD11A, LFA-1, LFA1A, integrin subunit alpha LExternal IDs 96606 1666 ITGAL Gene location (Human)16p11.2Start30,472,658 End30,523,185 Gene location (Mouse)Chromosome 7 (mouse)7 F3|7 69.44 cMStart127,296,260 End127,335,138 patternMore reference expression dataMolecular function• protein complex binding• metal ion binding• protein binding• protein heterodimerization activity• ICAM-3 receptor activity• cell adhesion molecule binding• macromolecular complex bindingCellular component• integral component of membrane• integrin alphaL-beta2 complex• membrane• cell surface• integrin complex• extracellular exosome• plasma membrane• specific granule membraneBiological process• leukocyte cell-cell adhesion• movement of cell or subcellular component• heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules• T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell• extracellular matrix organization• receptor clustering• cell adhesion• regulation of immune response• integrin-mediated signaling pathway• cell-matrix adhesion• inflammatory response• leukocyte migration• signal transduction• phagocytosis• neutrophil degranulation• cell-cell adhesionSources:Amigo / QuickGOSpeciesHumanMouse368316408ENSG00000005844ENSMUSG00000030830P20701P24063RefSeq (mRNA)NM_001114380NM_002209NM_001253872NM_001253873NM_001253874NM_008400RefSeq (protein)NP_001107852NP_002200NP_001240801NP_001240802NP_001240803NP_032426Location (UCSC)Chr 16: 30.47 – 30.52 MbChr 7: 127.3 – 127.34 Mb search. Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling. It is the target of the drug. Background: Integrin alpha L beta 2. Integrin alpha L beta 2, also called LFA-1, is one of three beta 2 integrin adhesion proteins. The non-covalent heterodimer of 180 kDa alpha L/CD11a and 95 kDa beta 2/CD18 integrin subunits is expressed on virtually all leukocytes (1-3)..
Integrin alpha L beta 2: Products. Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM).. Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds.. In our study, we have discovered chemokine-like functions for the cytokine MIF such as induction of leukocyte arrest on endothelial cells. Cell adhesion requires the activation, i.e. by arrest chemokines, of integrins on the cell surface, which subsequently interact with adhesion molecules, such as VCAM-1 and ICAM-1.. Abstract. Chemokine-induced activation of alpha 4 beta 1 and alpha L beta 2 integrins (by conformational change and clustering) is required for lymphocyte transendothelial migration (TEM) and entry into lymph nodes.. The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.. Alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc is a branched amino tetrasaccharide consisting of N-acetyl-beta-D-glucosamine at the reducing end having an alpha-L-fucosyl residue attached at the 3-position and an alpha-L-fucosyl-(1->2)-beta-D-galactosyl moiety attached at the 4-position..
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