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alpha 2b beta 3

alpha 2b beta 3

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alpha 2b beta 3
Glycoprotein IIb/IIIa - Wikipedia, Integrin alpha 2b beta 3 Products: R&D Systems, Platelet integrin alpha(IIb)beta(3): activation mechanisms., Anti-Integrin alpha 2b + beta 3 antibody [P256] (ab11027 , Recombinant Human Integrin alpha 2b beta 3 Protein, CF , Anti-Integrin alpha 2b + beta 3 antibody [IVA30] (GTX23919 , Active Human Integrin alpha 2b beta 3 Protein (His tag , Native human Integrin alpha 2b + beta 3 protein (ab95130 , ITGA2B integrin subunit alpha 2b [ (human)].
Integrin alpha 2b beta 3: ProductsIntegrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin. . In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin α IIb β 3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation.. Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi .
Integrin alpha(IIb)beta(3) plays a critical role in platelet aggregation, a central response in hemostasis and thrombosis. This function of alpha(IIb)beta(3) depends upon a transition from a resting to an activated state such that it acquires the capacity to bind soluble ligands. Diverse platelet agonists alter the cytoplasmic domain of alpha(IIb)beta(3) and initiate a conformational change . Mouse monoclonal Integrin alpha 2b + beta 3 antibody [P256]. Validated in WB, IP, ICC/IF and tested in Human. Cited in 3 publication(s). Immunogen corresponding to tissue, cells or virus.. Targeting of alpha 2b beta 3 by therapeutic antibodies or small molecules can inhibit formation of thrombi in patients with acute coronary syndrome, and potentially inhibits tumor angiogenesis and metastasis by blocking interaction of platelet alpha 2b beta 3 with tumor cells (1, 9).. Mouse Monoclonal Integrin alpha 2b + beta 3 antibody [IVA30]. Validated in FACS, IP, ELISA. Tested in Bovine. - professional antibody manufacturer.. Recombinant Integrin alpha 2b beta 3 Protein (His tag). Species: Human. Source: HEK-293 Cells. Order product ABIN5954892.. Buy our Native human Integrin alpha 2b + beta 3 protein. Ab95130 is an active full length protein produced in Nativesyntheticaly and has been validated in FuncS, SDS-PAGE. Abcam provides free….
 
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