ITGAMAvailable structuresOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2IdentifiersITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha MExternal IDs 96607 526 ITGAM Gene location (Human)16p11.2Start31,259,967 End31,332,892 Gene location (Mouse)Chromosome 7 (mouse)7|7 F3Start128,062,640 End128,118,491 patternMore reference expression dataMolecular function• metal ion binding• glycoprotein binding• protein binding• protein heterodimerization activity• heat shock protein binding• amyloid-beta binding• complement component C3b binding• cargo receptor activityCellular component• extracellular exosome• plasma membrane• cell surface• membrane• integral component of membrane• integrin complex• extracellular space• specific granule membrane• tertiary granule membrane• external side of plasma membrane• integrin alphaM-beta2 complex• plasma membrane raft• membrane raftBiological process• ectodermal cell differentiation• toll-like receptor 4 signaling pathway• integrin-mediated signaling pathway• leukocyte migration• extracellular matrix organization• cell adhesion• neutrophil degranulation• microglial cell activation• immune system process• receptor-mediated endocytosis• phagocytosis, engulfment• cytokine-mediated signaling pathway• positive regulation of superoxide anion generation• positive regulation of neutrophil degranulation• innate immune response• negative regulation of dopamine metabolic process• positive regulation of protein targeting to membrane• amyloid-beta clearance• cell-cell adhesion via plasma-membrane adhesion molecules• complement-mediated synapse pruning• vertebrate eye-specific patterning• positive regulation of neuron death• positive regulation of microglial cell activation• positive regulation of microglial cell mediated cytotoxicity• cell surface receptor signaling pathway involved in cell-cell signaling• positive regulation of prostaglandin-E synthase activity• forebrain development• apoptotic signaling pathway• positive regulation of hippocampal neuron apoptotic processSources:Amigo / QuickGOSpeciesHumanMouse368416409ENSG00000169896ENSMUSG00000030786P11215P05555RefSeq (mRNA)NM_000632NM_001145808NM_001082960NM_008401RefSeq (protein)NP_000623NP_001139280n/aLocation (UCSC)Chr 16: 31.26 – 31.33 MbChr 7: 128.06 – 128.12 Mb search. Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (α M β 2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B).. Human Integrin alpha M beta 2 protein (4047-AM) is manufactured by R&D Systems. Reproducible results in bioactivity assays. Learn More.