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alpha m beta 2

alpha m beta 2

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alpha m beta 2
Integrin alpha M - Wikipedia, Recombinant Human Integrin alpha M beta 2 Protein, CF 4047 , Integrin alpha M beta 2 Research Products: Novus Biologicals, Alpha M Beta 2 Integrin Blockade for Acute Inflammatory , Activation of alpha(M)beta(2)-mediated phagocytosis by HF3 , ITGAM integrin subunit alpha M [ (human)], STORRE: An essential role for talin during alpha(M)beta(2 , Interaction of fibrin(ogen) with leukocyte receptor alpha , Blood Vessels - PhysiologyModels.info.
ITGAMAvailable structuresOrtholog search: PDBe RCSB List of PDB id codes1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2IdentifiersITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha MExternal IDs 96607 526 ITGAM Gene location (Human)16p11.2Start31,259,967 End31,332,892 Gene location (Mouse)Chromosome 7 (mouse)7|7 F3Start128,062,640 End128,118,491 patternMore reference expression dataMolecular function• metal ion binding• glycoprotein binding• protein binding• protein heterodimerization activity• heat shock protein binding• amyloid-beta binding• complement component C3b binding• cargo receptor activityCellular component• extracellular exosome• plasma membrane• cell surface• membrane• integral component of membrane• integrin complex• extracellular space• specific granule membrane• tertiary granule membrane• external side of plasma membrane• integrin alphaM-beta2 complex• plasma membrane raft• membrane raftBiological process• ectodermal cell differentiation• toll-like receptor 4 signaling pathway• integrin-mediated signaling pathway• leukocyte migration• extracellular matrix organization• cell adhesion• neutrophil degranulation• microglial cell activation• immune system process• receptor-mediated endocytosis• phagocytosis, engulfment• cytokine-mediated signaling pathway• positive regulation of superoxide anion generation• positive regulation of neutrophil degranulation• innate immune response• negative regulation of dopamine metabolic process• positive regulation of protein targeting to membrane• amyloid-beta clearance• cell-cell adhesion via plasma-membrane adhesion molecules• complement-mediated synapse pruning• vertebrate eye-specific patterning• positive regulation of neuron death• positive regulation of microglial cell activation• positive regulation of microglial cell mediated cytotoxicity• cell surface receptor signaling pathway involved in cell-cell signaling• positive regulation of prostaglandin-E synthase activity• forebrain development• apoptotic signaling pathway• positive regulation of hippocampal neuron apoptotic processSources:Amigo / QuickGOSpeciesHumanMouse368416409ENSG00000169896ENSMUSG00000030786P11215P05555RefSeq (mRNA)NM_000632NM_001145808NM_001082960NM_008401RefSeq (protein)NP_000623NP_001139280n/aLocation (UCSC)Chr 16: 31.26 – 31.33 MbChr 7: 128.06 – 128.12 Mb search. Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (α M β 2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B).. Human Integrin alpha M beta 2 protein (4047-AM) is manufactured by R&D Systems. Reproducible results in bioactivity assays. Learn More.
Integrin alpha M beta 2 products available through Novus Biologicals. Browse our Integrin alpha M beta 2 product catalog backed by our Guarantee+.. Our objective is to evaluate whether inhibition of alpha M beta2integrin-dependent leukocyte infiltration into peripheral nerves is a specific therapy for acute. Literature citations. x; UniProtKB. Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and . This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1. Lim J, Wiedemann A, Tzircotis G, Monkley SJ, Critchley DR & Caron E (2007) An essential role for talin during alpha(M)beta(2)-mediated phagocytosis, Molecular Biology of the Cell, 18 (3), pp. 976-985.. The fibrinogen gamma-module sequences, gamma190-202 or P1, and gamma377-395 or P2, were implicated in interaction with the alpha(M)I-domain of the leukocyte receptor alpha(M)beta(2). P1 is an integral part of the gamma-module central domain, while P2 is inserted into this domain forming an antiparallel beta-strand with P1. We hypothesized earlier that separation of P2 from P1 may regulate .
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