β 2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells).. Lisa, The beta globulin is one of the values reported from a test called protein electrophoresis, which can be run on the blood (called serum protein electrophoresis - SPEP) or the urine (UPEP).. Beta 2-microglobulin is a protein found on the surface of many cells. Testing is done primarily when evaluating a person for certain kinds of cancer affecting white blood cells including chronic lymphocytic leukemia, non-Hodgkin's lymphoma, and multiple myeloma or kidney disease.. Alpha globulin range is 0.2-0.3 g/L and optimal beta globulin range is 0.7-1.0 g/L. The level of globulins can increase or fall below the optimal range. The level of globulins can increase or fall below the optimal range.. Beta-2-microglobulin (beta-2-M) is a small membrane protein (11,800 Dalton) associated with the heavy chains of class I major histocompatibility complex proteins and is, therefore, on the surface of all nucleated cells.. Ideally, albumin levels will fall at 4.5-5/100 ml, alpha globulin levels will remain at .2-.3 g/L and beta globulin levels will fall at .7-1.0 g/L. Low Globulin Levels. If the globulin levels fall below this normal range, it can be a sign of several serious health conditions..