Ideally, albumin levels will fall at 4.5-5/100 ml, alpha globulin levels will remain at .2-.3 g/L and beta globulin levels will fall at .7-1.0 g/L. Low Globulin Levels. If the globulin levels fall below this normal range, it can be a sign of several serious health conditions.. β 2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excludes red blood cells).. "Suppressed Beta 2 Globulin (1.6 g/L) reference range is 1.8 - 4.8 g/L. My Alpha 1, Alpha 2, and Beta 1 Globulins are all low - albeit still just inside the reference range.. Total serum globulin consists of individual globulin fractions called alpha 1, alpha 2, beta and gamma fractions. Thus the total globulin level is greatly affected by increases or decreases in one or more of these fractions.. Beta-2 microglobulin (B2M) is a protein shed by cells into the blood, including tumor cells. The B2M test can be used as a tumor marker for some people with blood cell cancers (multiple myeloma, lymphoma) to give information about their likely prognosis.. Beta 2 microglobulin is an 11.8-kD protein (see first image below), which forms one of the chains of the major histocompatibility complex (MHC) class I molecule normally present on the surface of every nucleated cell in the human body..