BESPONSA is associated with a risk of liver problems and increased risk of death after stem cell transplant. BESPONSA can cause liver problems that can be severe, life-threatening, or fatal, including a condition called veno-occlusive disease (VOD). This condition can occur during treatment with BESPONSA or following subsequent treatment with a stem cell transplant. This condition was more common in patients who had elevated liver tests or who received dual alkylating agents in preparation for their stem cell transplant. Patients may be at a higher risk of VOD if they:. BESPONSA is the first and only therapy approved to target CD22, a specific protein that occurs on the surface of ALL cells. HOW OTHER PATIENTS RESPONDED How was BESPONSA studied?. Several different therapies are available that target specific proteins on ALL cells, such as CD19, CD22, and CD20. Stem cell transplant. A procedure that replaces the blood-forming stem cells in your bone marrow with healthy cells, restoring normal blood cell growth. CAR T-cell therapy . A gene therapy that can help your immune system to better recognize and fight your cancer, used in .