FDA Approves BESPONSA (Inotuzumab Ozogamicin) for Adults with Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia On August 17, 2017,. TLV is true to the philosophy of complete customer satisfaction through strict adherence to its two fundamental policies: Quality First, Incomparable Originality. Besponsa is an engineered antibody that targets the CD22 protein on B cells combined with a small molecule drug that kills cancer cells. The conjugate enters tumor cells and releases the drug, which causes DNA breaks that stop cell multiplication.. A Steam Specialist Company Select your language. English (International) English (Asia) English (Australia). The FDA has approved inotuzumab ozogamicin (Besponsa) for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL), based on findings from the phase . The airport is located near Highway 1, the main Jerusalem-Tel Aviv Highway and Highway 40. The airport is accessible by car or public bus. The airport is accessible by car or public bus. Israel Railways operates train service from the airport to several parts of the country and taxi stands are located outside the arrivals building..