Dose and administration: Apply hydrocortisone cream to the affected area as a thin film 2 to 4 times daily depending on the severity of the condition. It is not likely other drugs you take orally or inject will have an effect on topically applied hydrocortisone. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, hydrocortisone should be used only when prescribed. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. Tell your doctor if you notice symptoms such as persistent nausea/, severe diarrhea, or in your newborn. This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding. . Compare Betaderm vs. Hydrocortisone, which is better for uses like: Itching, Eczema and Rash. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews.. Hydrocortisone is a weaker steroid and can be used on the face (never the scalp). I use it on his body when there are tiny little patches that I think they can contain. I use it on his body when there are tiny little patches that I think they can contain..