Beta-2 glycoprotein 1 antibody is a protein c-factro that binds to phospholipids. Phospholipids are lipid-proteins found in the outermost layer of cells (cell membrane) including blood cells such as platelets. In anti-phospholipid syndrome (APS) autoantibodies are produced that target phospholipid and its co- . In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β 2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. . Beta-2 glycoprotein 1 (beta-2 GP1, also called apolipoprotein H) is a 326-amino acid polypeptide synthesized by hepatocytes, endothelial cells and trophoblast cells.. Miyakis S(1), Giannakopoulos B, Krilis SA. Author information: (1)Department of Immunology, Allergy and Infectious Diseases, University of New South Wales, St. George Hospital, 2 South Street, Kogarah, NSW 2217, Australia. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in. . .